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Phase 2 trial data showing up to 24% body weight reduction over 48 weeks put it ahead of every approved therapy currently on the market

Tumour xenografts All animals were bred on a mixed genetic background

In addition, metformin could regulate DNA/histone modifications and miRNAs to carry out transcriptional regulatory processes (

The effects and mechanisms of active compounds in CHMs on DOR In modern medical research, the impact of active compounds in TCM on DOR has garnered increasing attention

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AI-driven analyses can uncover novel compounds and predict their senescence-modulating properties based on biological data.206 Moreover, systems biology approaches that analyze the complex networks of cellular aging processes could help uncover new targets for senomorphic therapies and optimize their clinical applications.207 Combination Therapies: Synergizing Senolytics and Senomorphics While both senolytics and senomorphics offer promising approaches for targeting cellular senescence, recent research suggests that combining these two therapeutic strategies may enhance their individual benefits, leading to more robust outcomes in promoting healthy aging