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The improved functioning of the BBB, enhanced clearance of metabolites and protein fragments implicated in AD from the brain - an astrocyte-dependent mechanism primarily occurring during sleep [14] - and enhanced insulin signaling, suggested to play a role in AD [33], present additional mechanisms by which melatonin may impact AD pathology

Cells (2021) 10(11):3145

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Abstract Metabolic reprogramming has been widely recognized as a hallmark of malignancy

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