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Evidencia (pembrolizumab): En un ensayo de fase II de un solo grupo (KEYNOTE-629 [NCT03284424]) se inscribi a 105 pacientes en la cohorte de CCE recidivante o metastsico.[6] Se exigi que los pacientes tuvieran una enfermedad mensurable y se excluy a aquellos con una enfermedad autoinmunitaria o una afeccin para la que se necesitara inmunodepresin o tuviera un grado superior a 1 segn el Eastern Cooperative Oncology Group Performance Status

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These multifaceted mechanisms demonstrate why ALA and L-carnitine co-supplementation offers a comprehensive approach to migraine management, targeting multiple pathophysiological pathways simultaneously