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Superoxide anion (O 2 ) and hydrogen peroxide (H 2 O 2 ) are produced in mitochondria, endoplasmic reticulum (ER), peroxisomes, and the cytosol by enzymes including respiratory complexes (Turrens 2003), NADPH oxidases (NOX) (Bedard and Krause 2007), uncoupled nitric oxide synthase (Montezano and Touyz 2012), monoamine oxidase (Pizzinat et al
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Furthermore, the expression of genes associated with mitochondrial biogenesis, including PGC-1, Nrf1, NRF2, and TFAM, was observed to have decreased in brain tissue samples from AD patients (Kerr et al., 2017)

Higher levels of glutathione help to slow aging, clear the body of toxins, and prevent disease

Rather, it might be related to the metabolic activity of pineal gland per se

Safamariyam, K.P
