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Inactivating circulating dopamine may be important as variations in the ability to sulfo-conjugate dopamine increases the risk of certain diseases (Suominen et al., 2015)
15 It may play a role in cell signaling within the bone marrow, modulating cellular interactions, particularly during the normal development of lymphocytes

The ATP-depleting futile 5-oxoproline cycle can also contribute to other acute and chronic acetaminophen toxicity syndromes
