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The 93% amino acid identity between human and rat orthologs suggested that CYP51A1 functions as a highly conserved housekeeping enzyme essential for survival [13, 14]

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Chem Biol 15:234245 Wewer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS
