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J Immunol 177:26302637 Holmguist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Munch G (2007) Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

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However, additional findings, including renal alterations in juvenile rats and renal alterations and retinal dysplasia in neonatal rats, have been reported

Thus, at the level of overall glucose homeostasis the AMPK-mediated activation of PDE4B will counter all of the cAMP-PKA-mediated effects in hepatocytes that are stimulated by glucagon as well as those exerted by epinephrine binding to hepatic 2 -adrenergic receptors