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However, the major mechanism for control of the alternative pathway appears to be posttranscriptional and involve the regulation of cholesterol delivery to the mitochondrial inner membrane, the site of cholesterol 27-hydroxylation

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Elevated secretion of the cytokines TNF-, IL-6, and IL-1 is associated with elevated neuronal inflammation, which is accompanied by decreased expression of anti-inflammatory mediators including IL-10 (9)

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