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Mitochondrial metabolism and KRASMAPK axis in CRC chemoresistance Although chemotherapeutic agents such as 5-FU, oxaliplatin, and irinotecan remain central to CRC treatment, the metabolic adaptability of tumor cells continues to undermine their long-term efficacy [23]

C., Varadharajan, K., Shanmugakonar, M

10.1016/j.clinthera.2014.07.017 30 DengY

Further validations in terms of specificity, sensitivity, and reproducibility in larger populations (including children as well) will be required for these new markers before applications in routine clinical practice

doi: 10.1186/1476-511X-9-79

Once again, the reasons of such difference have not been established yet