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Dilated blood vessels offer less resistance to blood flow, and reduced resistance means lower pressure for any given cardiac output

It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]

The research base is, in effect, the output of one laboratory and its collaborators over thirty years

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M., Keov, P., Mariam, Z., Deganutti, G., Christopoulos, G., Hick, C

Others point to dehydration, since increased lipolysis generates metabolic water demands