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The gradual death of neurons, resulting in a loss of brain function, such as cognition, age-related dysregulation of biochemical pathways, and alterations of gene expression, is poorly understood and current therapies are still ineffective

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ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease

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Currently, there is no safe and effective drug to prevent excitotoxicity
