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Nrf2 knockout mice exhibited an amplified incidence and severity of cataracts [20], reinforcing the pivotal role of Nrf2 in oxidative damage and cataractogenesis prevention

In PCa, metabolic reprogramming disrupts this homeostasis through sequential and interconnected mechanisms

The animals were anesthetized by inhalation route with Isofluorane (Isboa Vet) using a vaporizer and intranasal administration was performed with two instillations of 20 l of the bacterial suspension prepared in PBS

While no direct epigenetic regulator of DAT endocytosis has been identified, DNA methyltransferases can indirectly affect this process by altering the expression of genes involved in key signaling pathways, such as protein kinase C and D2 receptor systems (Su and Liu, 2017)