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In studies reporting event counts, ALC arm events were mainly categorized as gastrointestinal (GI) and central nervous system (CNS), with other systems (skin/subcutaneous, urinary, cardiovascular, endocrine/metabolic, reproductive) reported infrequently

LA plays an important role in mitochondrial energy metabolism while acting as an essential cofactor for mitochondrial -ketoacid dehydrogenases (Solmonson et al ., 2018)

Moreover, inhibiting the mechanistic target of rapamycin has been demonstrated to decrease the incidence of BIPN in preclinical models (Suzuki et al., 2023)

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The company plans to begin this year with phase IB, which will treat four people with MSA and four patients with PD