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The induction of the early oxidative stress events by R001 triggered unrecoverable DNA damage [40, 41] that occurs late following the treatment of the TNBC cells with the natural product

Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids and other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death

Curr Opin Drug Discov Dev 6:675682 Griffin S, Clark JB, Canevari L (2005) Astrocyte-neurone communication following oxygen-glucose deprivation

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As-prepared QDs-GSH, thanks to their stabilization via electrostatic repulsion (zeta potential in the stability window) and negligible, negative impact of GSH oxidation, turned out to be quite stable in aqueous solution