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In summary, these results suggest that PM 10 exposure induces a selective, uricase-sensitive antigen-specific CD4+ T-cell proliferation that is independent of changes in Treg numbers

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doi: 10.1111/j.1600-0676.1987.tb00368.x

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Notably, these alterations occur prior to the onset of inflammation and induce the upregulation of epithelial-derived cytokines such as thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33), which subsequently activate the Th2 immune axis in a sustained manner (Jo et al., 2018

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