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The impact depends on: Whether a true deficiency is present Whether the supplement alters hormonal signalling Whether it changes inflammation or tissue metabolism The degree of influence varies significantly between nutrients

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Porter & Bennett, 1989), it may simply be a convenient marker for the change in renal vulnerability that relates to the decline in glomerular filtration rate (GFR) occurring beyond the age of 50 (Davies & Shock, 1950)

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However, the secretion of the anti-diuretic hormone (ADH) in response to increased plasma osmolality occurs at a lower threshold than the threshold for thirst, around 280 mOsm/kg versus 290-295 mOsm/kg respectively ( Bouby and Fernandes 2003

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Rights and permissions About this article Cite this article Kahn, S.E., Buse, J.B

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