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NAD+-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not affect mitochondrial function or skeletal muscle function in physically compromised older adults

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Severe deficiencies may lead to anemia and nerve damage if left untreated

In some embodiments, the otoprotectant is a compound comprising a urea-thiophene-carboxamide moiety of Formula (IV): wherein X is a heteroatom that includes N, 0, or S