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doi: 10.3389/fphar.2024.1410479 Received 01 April 2024 Accepted 21 May 2024 Published 11 June 2024 Volume 15 - 2024 Edited by Lin Zhu, Vanderbilt University Medical Center, United States Reviewed by Feng Liu, Soochow University Medical College, China Kenneth Maiese, National Institutes of Health (NIH), United States Updates Copyright 2024 Sun, Zhu, Li, Mei, Li and Li

Experimental examination and microscopic cartilage structure analysis in affected joints have indicated positive results upon AOD 9604 influence in osteoarthritis test subjects

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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007