microsomal glutathione s transferase 2 Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione-S-Transferases as Potential Targets for

Increased levels of cytoplasmic ROS are generated through increased metabolic activity, mitochondrial dysfunction and oncogene activity which drive critical signalling pathways to sustain hyperproliferative growth 4 and inflammation 3

Reference: arXiv preprint (not peer reviewed) Features & opinion A unique collection and collector Molecular palaeontologist Alexandra Morton-Hayward investigates why a small proportion of ancient brains somehow resist the decomposition process that begins to destroy most soft tissue within hours after death

Similarly, a study on corneal endothelial cells reported that TNF- disrupts gap junctional intercellular communication (GJIC) in the corneal endothelium by interfering with the connection between Cx43 and zonula occludens-1 (ZO-1)

Available online at: (Accessed January 10, 2025)

Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses

Scientists are also targeting metabolic functions beyond cholesterol, because the brain handles energy differently as Alzheimers disease develops