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Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

3-5 servings of coffee a day which appear to be the minimum needed for the long term neuroprotection, may have some cardiovascular liabilities, particularly in subjects with underlying conditions such as existing cardiovascular disease, smoking, a sedentary lifestyle and heredity factors that make them prone to high cholesterol and/or other cardiovascular maladies

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Proton pump inhibitors reduce the bioavailability of dietary vitamin C

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Surgical interventions are considered the gold standard treatment for PD, especially for the correction of penile deformity [69, 70]