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Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death
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In a study by Kraus et al., NNMT inhibition in obese mice not only reduced fat mass but also spared lean muscle mass , suggesting that the compound does not induce general catabolism, a common side effect of many weight-loss agents (Kraus D, 2014)
That all worked fine for over a year
They might do blood tests showing improvement (e.g., better red blood cell indices once B/B levels normalize)
