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The complexity of redox signaling in neoplasms underscores its potential as both a pathogenic hallmark and a therapeutic vulnerability

doi:10.1016/j.bpg.2013.06.013

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In animal models it was shown that down-regulation of the GH/IGF-1/insulin system significantly prolongs the lifespan

Yet, the available preclinical data also report a favorable safety profile [4, 26, 27, 28]

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