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the former signals poorer outcomes and the latter defines a higher activity tier, underscoring that cutoff selection depends on study objectives (129, 130)

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Loske C, Neumann A, Cunningham AM, Nichol K, Schinzel R, Riederer P, et al

However, more recent evolutionary coevolution analyses and microscopy work demonstrate that ZnT9 predominantly localizes to mitochondria and functions as a zinc exporter, with loss leading to mitochondrial zinc overload and dysfunction 39

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