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Description
In fact, therapeutic doses of metformin (150 M) protect endothelial function by interacting with the orphan nuclear receptor Nur77/NR4A1 to reduce hyperglycaemic-induced ROS [113]
ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)
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Cohen SA, Kasi PM, Aushev VN, Hanna DL, Botta GP, Sharif S, Georgios I Laliotis MD, PhD, Sharma VR, Alqahtani A, Chandana SR, Kang S, Chakrabarti S, Somer BG, Kasi A, Dayyani F, Malla M, Jurdi AA, Liu MC, Aleshin A, Kopetz S
