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Fatty acids and glucose can feed acetyl-CoA pools and histone acetylation independent of ACLY and ACSS2 To determine if fatty acid oxidation contributes substantially to the acetyl-CoA pool in DKO cells, we used stable isotope tracing of uniformly labeled 13 C palmitate ( 13 C 16 -PA) into whole cell acetyl-CoA pools (Figure 5A)

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31 Mean pain intensity score, evaluated using the modified short-form MPQ, was significantly lowered during the study, whereas electrophysiological parameters did not show significant changes