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It can be used alongside caloric restriction without exacerbating hunger, combined with exercise programs without compromising fueling needs, or integrated with behavioral nutrition approaches that rely on intact hunger and satiety signaling for long-term habit formation

A standard cycle runs 12 weeks on followed by 4 weeks off

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The method of administration of precursors also influences NAD + fluxes in the body, as uncovered by precursor tracer experiments in mice