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L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, cyt C and CASP-3 signaling

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The authors proposed that L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons and suggested that this attenuated cognitive impairment after chronic hypoperfusion [86] However, the increased CPT I and CPT II protein levels in L-carnitine treated rats may also have protected myelin after chronic hypoperfusion

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ALC is a highly bioavailable form of L-Carnitine that can cross the blood-brain barrier, where it helps to manage oxidative damage, supports mitochondrial function and helps to maintain normal neurotransmitter activity