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The research paper, Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study , was published in the Journal of Neurology, Neurosurgery & Psychiatry

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This process supports cellular regeneration, reduces inflammation, and enhances the bodys ability to recover from oxidative stress

Under proteotoxic or oxidative stress, NRF1 is cleaved by DDI2 and translocated to the nucleus to activate genes encoding proteasome subunits, establishing a feedback response

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[DOI] [PMC free article] [PubMed] [Google Scholar] Cho H.S., Kim S., Lee S.Y., Park J.A., Kim S.J., Chun H.S