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5.4 Comparative therapeutic efficacy The translation of therapeutic agents from animal models to clinical trials faces significant barriers

This study suggests that GSH depletion contributes to the heightened cardiovascular risk in diabetic patients

Lipper CH, Stofleth JT, Bai F, Sohn YS, Roy S, Mittler R, et al

The results showed a significant and dose-dependent increase in the expression of tumor suppressor proteins p53, Ras p21, and JNKs (Jun-N-terminal kinase) in blood samples of 3185-year-old COPD patient samples after 6 h of ZnO treatment at the 10, 20, and 40 g/ml concentrations (Kumar et al., 2015)

doi: 10.1152/physrev.00018.2001

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