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In addition, fasting-induced improvements in insulin sensitivity and reductions in systemic inflammation may indirectly support gonadal steroidogenesis by restoring optimal Leydig cell responsiveness, which is crucial for testosterone production [58]
VDR also regulates the CYP27B1 gene, which encodes the enzyme responsible for converting vitamin D to its active form, suggesting an intricate feedback mechanism in vitamin D metabolism [46]
Cell 148 , 4657 (2012)
J Neuropathol Exp Neurol 73: 10261033, 2014
