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There are also several non-enzymatic antioxidants involved in the antioxidant defense system

Furthermore, a disruption in mitochondrial cysteine metabolism could explain the gradual loss of mitochondrial function reportedly associated with prolonged cysteine deprivation 3,15,22,23

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The downstream effects of the two enzymes are opposite: ACE activity leads to vasoconstriction, oxidative stress, inflammation and apoptosis, whereas ACE2 causes vasodilatation, angiogenesis and anti-inflammatory, anti-oxidative and anti-apoptotic effects [1]

Hatschek, T