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Additionally, patients with renal or hepatic impairment may have altered glutathione metabolism and require individualized dosing assessment

Evaluation of high dose N- acetylcysteine on airway inflammation and quality of life outcomes in adults with bronchiectasis: a randomised placebo-controlled pilot study

Yakovleva O, Bogatova K, Mukhtarova R, Yakovlev A, Shakhmatova V, Gerasimova E, Ziyatdinova G, Hermann A, Sitdikova G (2020) Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress

10.1165/rcmb.2017-0289OC 54 HuB.Gharaee-KermaniM.WuZ.PhanS

Therefore, while these results provide valuable early data, they must be interpreted with caution

To avoid the non-linear constraint imposed in equation (4) two variables, y + and y , are introduced to convert the problem to its equivalent linear form