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MOTS-C (Mitochondrial Open-Reading-Frame of the 12S rRNA-C) is a mitochondrial-derived peptide that plays a crucial role in metabolic regulation

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Abstract To develop an LCMS/MS method for simultaneous quantification of mildronate and L-carnitine, and to investigate the pharmacokinetic profile of mildronate in rats, its effect on L-carnitine homeostasis, as well as the exposure characteristics, underlying mechanisms, and their associations with therapeutic efficacy and toxicity risks

Pasireotide for the medical management of feline hypersomatotropism