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This could be achieved by engineering the core and/or the shell of microcapsules to protect the bioactives from potential chemical degradation, harsh GI environment, and control its release

Circulating Insulin-Like Growth Factor-1 and Risk of Total and 19 Site-Specific Cancers: Cohort Study Analyses from the UK Biobank

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10.1038/nri2765 193 MocsaiA.ZhouM

Across a cohort of NSCLC patients, those with KEAP1/NRF2 mutant tumors had a nearly 60% rate of locoregional failure after chemoradiation relative to 20% in the KEAP1/NRF2 wildtype cohort [51]