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References [1] Voskuhl R

2013(10):Cd010391
Hematology 20 , 311312 (2015)

SPIRITT: a randomized, multicenter, phase II study of panitumumab with FOLFIRI and bevacizumab with FOLFIRI as second-line treatment in patients with unresectable wild type KRAS metastatic colorectal cancer

This schedule uses higher total blend volumes

However, one drawback of these advanced devices is that they require a certain level of patient compliance and are less convenient to use than traditional nasal spray
