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Poordad, F, McCone, J Jr, Bacon, BR, et al
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Neuropathological hallmarks of the disease include the abnormal deposition of amyloid -peptide (A) fibrils, the main component of senile plaques (SPs), and the intracellular accumulation of neurofibrillary tangles (NFTs), composed of hyperphosphorylated Tau protein (pTau)

Moreover, the pentamer dissociates into mCRP and triggers angiogenesis by stimulating F3 transcription and tissue factor signaling in the membranes of microvascular endothelial cells [94]

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