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Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation

Reduced labile iron content in M(Hb) macrophages is associated with less ROS production which is linked to increased activity of the transcription factor liver X receptor- and the induction of cholesterol efflux (105)

Pharmacol Ther 173:135145

10.1111/nyas.15187 22 GrantB.KeanJ.ValiN.CampbellJ.MadenL.BijralP.et al (2023b)

However, further experiments are needed to determine the exact relative contributions and to uncover the molecular mechanism behind the observed increase in total cellular GPX4 protein levels following LDHB silencing (Fig

Mitochondria: more than just a powerhouse