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Animal experiments have shown that choline or carnitine supplementation markedly (approximately 30%) reduces reverse cholesterol transport (RCT) in mice compared to normal chow controls, a process that can be completely inhibited by oral broad-spectrum antibiotics ( Preventions and Treatments Targeting TMAO Because TMAO is possibly a new high-risk factor for AS diseases, the prevention and treatment of AS through targeting TMAO require increased attention, which this paper provides as follows

In addition to effects on ion channel expression, metabolic changes produced by the diet could cause functional alterations in ion channel activity

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