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SaitoS.IidaA.SekineA.MiuraY.SakamotoT.OgawaC.KawauchiS.HiguchiS.NakamuraY.2001Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population.469(2001),529537,1434-5161 96

MNPs can provoke ER stress both indirectly via ROS generation that perturbs ER redox balance and protein folding [159], and directly by being internalized and causing ER swelling and physical disruption [160]

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In doing so, this review intends to provide a more up-to-date and comprehensive perspective to the existing literature

Ocular delivery: MSNs offer controlled release in ocular spaces (conjunctiva, vitreous), counteracting the fast drainage and short residence time of traditional eye drops