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A vital component of the fibrous cap is collagen, and macrophage-derived TGF- stimulates its production (Figure 4) (142)

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The equations are discretized using centered second-order accurate differencing schemes in space, explicit first-order accurate in time

Neccrostatin-1 (Nec-1), the necroptosis inhibitor by targeting RIPK1, can inhibit RPE cell death by inhibiting both lipid ROS accumulation, providing further evidence that lipid peroxidation drives the occurrence of necroptosis [73]