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They modulate the expression of hepatic glucose and lipid metabolism-related genes primarily through FXR and GPBAR1, thereby exerting indirect effects on lipid metabolism and overall energy homeostasis [32]
80 Additionally, mitochondrial calcium handling plays vital roles in regulating apoptosis, where excessive calcium can trigger cell death pathways
Advanced immunosuppression is a known risk factor and even single episode of pneumonia is associated with increased morbidity and mortality [6]
Diabetes Obes Metab 2017;19:15218.PubMed 14
10.1136/gutjnl-2018-317431 57
