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25 DaveyA

[DOI] [PMC free article] [PubMed] [Google Scholar] Naqvi S, Zhu C, Farre G, et al

PMC 3228169
10.1155/2019/1845321 168 Gilardini MontaniM

Furthermore, impaired cerebral metabolism appears to be an early-stage biomarker for ADRD, as several studies have shown reduced glucose metabolism in the hippocampus and posterior cingulate prior to observation of overt clinical symptoms (i.e., cognitive impairment) (Kumar et al., 2022

This was suggested to have occurred through the activation of 5 AMP-activated protein kinase (AMPK) and the reduction of total AMPK protein content in the gastrocnemius (GAST) muscle of ob/ob mice (189), thereby favoring an increase in carbohydrate oxidation, rather than an increase in fatty acid oxidation
