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While collagen provides the structural framework, glutathione protects that framework from being broken down by environmental stressors

The pan-caspase inhibitor emricasan has been under investigation for patients with severe AH (NCT01912404), but the trial was halted prematurely due to concerns regarding suboptimal drug bioavailability, which led to a reduction in the safe dosage

( A ) Immunofluorescence microscopy of HEK293T cells transfected with either a non-targeting control (NTC) siRNA for 48 h, NTC siRNA for 48 h and treated with MG132 (10 m, 8 h), PDIA3 siRNA for 48 h or PDIA6 siRNA for 48 h, using p62 as a marker for aggresomes/aggregated proteins

Moreover, the PINK1 activator ABBV-1088 (Mitokinin/AbbVie) and the USP30 inhibitor MTX325 (Mission Therapeutics) are both entering Phase 1 clinical trials as the first selective mitophagy enhancers to treat PD

Addressing these issues is now the main challenge for GST functional genomics, and continued analysis of this protein superfamily will no doubt reveal many other examples of their functional diversification