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doi: 10.1016/j.mehy.2012.06.007 [DOI] [PubMed] [Google Scholar] 155

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In experiments involving a mouse model of skin aging induced by D-galactose, treatment with higher concentrations of sea buckthorn PCs (50 and 100 mg/kg) led to an increase in TGF-1 levels within the skin tissue and the upregulation of Smad3 expression

In another in vivo study, the absence of 5 nAChR in hemiparkinsonian mice was associated with reduced dopaminergic neurodegeneration and motor dysfunction, suggesting that nAChRs containing the 5 subunit may represent novel therapeutic targets for PD

Whilst the true (not anecdotal or case reports) effects on melasma are lacking via large studies there are some reports that it can help with melasma pigmentation, especially in combination with procedures such as lasers & novel chemical peels

The ratio of GSSH to GSH in the body helps provide an important indication of oxidative stress