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Thus, passive diffusion of peptides is very limited unless the peptides possess an amphipathic structure or use synthetic means to modify the lipophilicity [2,6], such as the glycosylation strategy of peptides [12]

doi: 10.1179/147683008X301540

Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY et al

Yet genetics highlight PIF4s privileged rolewithin the PIF quartet (PIF1, PIF3, PIF4, and PIF5), only loss of PIF4 markedly dampens thermosensory hypocotyl elongation, whereas single knockouts of the others have minimal effect 7,93

Advances in Colloid and Interface Science