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Phase I enzymes mediate oxidation, reduction, and hydrolytic reactions of xenobiotics, including NQO1, carbonyl reductases (CBRs), aldo-keto reductases (AKRs), and aldehyde dehydrogenase 1 (ALDH1), and certain cytochrome P450 oxidoreductases cytochrome P450s (CYPs) [71]
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52 The hallmark features of COPD pathology are displayed in Figure 1
However, the pathways behavior depends heavily on cellular context
Hence, the upregulation of the thiamine/ThDP-dependent protein transcripts 69 months after gastric bypass (Figures 4B, 5B) maybe a biochemical indicator of thiamine insufficiency in the enterocytes
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