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ROS mainly include hydroxyl radicals (OH), superoxide anions (O 2 ), singlet oxygen ( 1 O 2 ), and hydrogen peroxide (H 2 O 2 ) [5]

TMEM106B homozygous KO ( Tmem106b / ) mice are viable and fertile and exhibit no overt behavioral deficits during developmental and adult stages, but show minor myelination deficits in histopathological analysis [132, 187], consistent with human evidence that a de novo mutation in TMEM106B causes HLD [77]

27 Dosages have been in the range of 300500 mg of ashwagandha extract (twice a day)

doi: 10.1016/j.bbamcr.2018.02.010 48 YamamotoMKenslerTWMotohashiH

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Table 2 Examples of key probiotic species, their mechanisms of action, and clinical applications