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In postmenopausal women, who often present with increased arterial wave reflection and reduced muscle function, CIT shows meaningful vascular benefits

Hauser RA, Olanow CW, Dzyngel B, Bilbault T, Shill H, Isaacson S, Dubow J, Agro A

This is caused by a sudden decrease in blood flow to the brain

Furthermore, their quinidinelike effect on cardiac conduction, which can prolong the QTc interval, necessitates careful cardiovascular screening and often precludes their use in elderly patients or those with preexisting heart disease, frequently positioning them as a secondary choice after SNRIs or gabapentinoids [45, 336, 368, 369]

Sleep disruption is nearly universal as you toss and turn trying to find comfort

J Pediatr 228: 240251.e2, 2021