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For example, severe neuroinflammation (brain fog) can dysregulate the autonomic nervous system, leading to worsened POTS symptoms (tachycardia), which in turn triggers mast cell degranulation (histamine release)

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In addition, it can cause insomnia- high cortisol levels interfere with regular sleep patterns

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However, alcohol poisoning can occur more rapidly based on factors like low body weight, drinking on an empty stomach, dehydration, drinking at a fast pace, taking medication, and more