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Huemer M, Diodato D, Schwahn B, et al

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A Reminder of the Methylation Process S-adenosyl methionine (SAM) is the universal cofactor for methylation as the methyl group donor (Figure 1)

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LXRs act as ligand-dependent transcription factors that form heterodimers with the retinoid X receptor (RXR), which then bind to LXR-responsive elements (LXREs) in DNA to promote the expression of target genes